2015 Annual Meeting

SC53-Problems, Pitfalls and an Integrated Approach to Lymphoproliferative Disorders in the Skin

2015 Annual Meeting

Room CC 304, March 25 2015, 1:30pm to 5:30pm

Melissa P. Pulitzer, John R. Goodlad

Educational Objective

Diagnosis and classification of cutaneous lymphoproliferative disorders (CLPDs) is heavily reliant upon the careful integration of clinical, morphologic, immunohistochemical and molecular findings. Each of these categories of data is subject to technologic and/or interpretive pitfalls, which can confound a diagnosis despite the findings in the other areas. This course aims to review common causes of misdiagnosis pertinent to each of these four areas, emphasizing the importance of an integrative approach. This is a practically orientated course that will be delivered via self-study, presentation and discussion of eight cases that will illustrate specific problems that hinder correct interpretation of clinical, morphological, immunohistochemical and genetic findings. In particular we will address clinical presentations shared by different disease entities, morphological features common to different CLPDs, distinctive immunophenotypic markers shared by different CLPDs, and practicalities and pitfalls in the use of molecular studies. The main objective of the course is to provide the participant with an up-to-date tool-kit for accurately identifying distinct subtypes of cutaneous lymphoma and for differentiating benign atypical lymphoid infiltrates from T- and B- cell lymphomas in the skin. The course is suitable for senior residents, fellows in dermatopathology, hematopathology and surgical pathology, and for practicing general surgical pathologists, dermatopathologists, and hematopathologists. It is designed as a case-based study of molecular data, virtual slides, and gross (clinical) images. Cases will be made available as images and virtual slides via the USCAP website before the meeting. Multiple choice questions will accompany the images, for submission of responses prior to the meeting, and for discussion during the course. All course registrants will also receive access to the Powerpoint presentations used in delivering the course along with the text portion of the syllabus. Upon completion of the course, participants should be able to:

  1. understand the importance of a multidisciplinary approach in diagnosing CLPDs,
  2. have a working knowledge of important non-neoplastic (pseudolymphomatous) mimics of cutaneous T and B cell lymphomas,
  3. be aware of potential interpretive pitfalls in the distinction of reactive and neoplastic cutaneous lymphoid infiltrates, and in the subclassification of T and B cell lymphomas in the skin,
  4. understand the changing significance of important immunohistochemical stains as diagnostic and predictive biomarkers in cutaneous T and B cell lymphomas,
  5. have developed an understanding of the use of key molecular tests in the diagnosis and management of cutaneous lymphoma.

Session Credits: CME = 3 / SAMs = N/A


Speaker: Melissa Pulitzer, MD, Memorial Sloan Kettering Cancer Center, New York, NY
Access to Handouts
Speaker: John R. Goodlad, MD, Western General Hospital, The University of Edinburgh, Edinburgh, UK


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