2015 Annual Meeting

SC34- Non-invasive Nightmares in Breast Pathology

2015 Annual Meeting

Room CC 302, March 25 2015, 1:30pm to 5:30pm

Timothy Jacobs, Yunn-Yi Chen

Educational Objective

NEW COURSE Non-invasive lesions of the breast frequently present diagnostic difficulties for pathologists in their daily practice. Intraductal lesions per se are often challenging to distinguish amongst those which are benign, atypical or carcinoma in situ. Furthermore, non-invasive lesions (either benign or in situ carcinomas) may mimic invasive carcinomas, and vice versa. This course will include both common as well as less frequently seen non-invasive breast lesions which pathologists and pathologists in training would encounter in their breast pathology practice, and will provide diagnostic strategies useful in recognizing and distinguishing these potentially hazardous cases. Topics to be covered will include recurrent areas of difficulty and include: problematic benign intraductal proliferative lesions and atypical hyperplasia, difficulties involving ductal carcinoma in situ, columnar cell lesions and related issues, lobular neoplasia and variants, the spectrum of papillary lesions, mucocele-like lesions, sclerosing and pseudoinvasive lesions, and invasive carcinomas which mimic non-invasive entities. A case-based teaching approach will be utilized and will be extensively illustrated with examples drawn from the presenters’ routine daily sign-out and consultation practices. Presentations will strongly emphasize morphologic features throughout and will also integrate ancillary techniques such as immunohistochemistry and molecular pathology, highlighting their strengths and limitations. Helpful tips which the presenters find useful in their own daily practice will be liberally shared with participants. All cases to be discussed will be available to registrants prior to the course as web-based whole-scanned virtual slides, complimented by static digital images and accompanied by pertinent clinical histories. A comprehensive syllabus will be available online at the time of the course, and after the course all updated PowerPoint slides will available on the USCAP website. Upon completion of the course, participants will be more familiar with both common and rarer non-invasive lesions of the breast, as well as their mimickers, and will be equipped with diagnostic approaches to effectively recognize and distinguish such entities in their daily practice of breast pathology. Upon completion of this educational activity, participants should be able to:

  1. Become familiar with common as well as rarer problematic non-invasive lesions of the breast that may be encountered in daily pathology practice.
  2. Be equipped with diagnostic approaches and strategies to effectively recognize and distinguish non-invasive lesions, thereby reducing errors of diagnosis.
  3. Effectively utilize morphology and where appropriate integrate ancillary studies (such as immunohistochemistry and molecular pathology) while understanding strengths and limitations of these techniques.

Session Credits: CME = 3 / SAMs = N/A


SC Speaker
Speaker: Timothy W. Jacobs, MBChB, Virginia Mason Medical Center, Seattle, WA
Access to Handouts
SC Speaker
Speaker: Yunn-Yi Chen, MD, PhD, University of California San Francisco, San Francisco, CA
Access to Handouts


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